Then the allergy is switched on at that time and the pain which follows the muscle damage, and which persists long term is mis-attributed to damage, when actually it is sensitisation. This is a vast topic and I have included only a brief summary here, for completeness. It plays many vital roles, such as energy production and protection from oxidative cell damage. The term dates from when criminals aboard old sailing ships were secured to the deck with leg-irons, unable to move. So, to be blunt to the point of rudeness, you have to “get your shit together” and hold it there even as you worsen. This paper has been an exercise in collation. Initially the body copes surprisingly well as it gears up with thyroid and adrenal hormones to kick our mitochondrial engines into generating more energy to cope with these demands. Coenzyme Q10 as ubiquinol – 100 milligrams daily; Vitamin B12 is an excellent antioxidant - 1 milligram (1000 micrograms) by daily injection. Worse still, these foods provide a very short-term, addictive buzz of energy. Coenzyme Q10 (CoQ10) is a natural antioxidant synthesized by the body, found in many foods, and available as a supplement. Organ meats like liver have the highest concentration, though some legumes, nuts, seeds, and vegetables also have the compound. Probably the type of reaction depends on how much of the food is being consumed – regular consumption results in chronic low grade spasm and cramp, but the odd inadvertent exposure in somebody who is normally avoiding that food can cause acute lancinating pain so severe that the sufferer literally collapses. This can be summarised as below, although for each sufferer, this will be expressed in different way: Inability to cope with situations that previously the CFS/ME sufferer would have sailed through --> The first one is Co-enzyme Q10 and the other is vitamin B supplements, as both help with energy levels. por Susana1 » 22 Jul 2015, 00:00, Mensaje Some soldiers entered the house of Archimedes and one of the soldiers asked Archimedes who he was. These toxins then bio-accumulate in the heart, brain, bone marrow and kidneys – places where the liver cannot get at them. If it cannot access selenium then it will grab something which ‘looks’ similar, such as lead or mercury. One falls into CFS/ME as a result of a perfect storm whose foundation stones are poor diet and inadequate sleep, compounded by overwhelming demands which may be physical, mental, emotional and/or financial. However this progression means, to use a nautical analogy, you are sailing close to the wind. What makes this journey worse are vicious cycles. That’s important. It comes in two forms: ubiquinol, the active antioxidant form, and ubiquinone, the oxidized form, which the body partially converts to ubiquinol. This page was last modified on 14 April 2020, at 13:50. At least 1 milligram (1000 micrograms) daily. Do as many of these things at the same time as you can. This sets up a vicious cycle here because these are the very foods which result in metabolic syndrome, fermenting gut, allergy and micronutrient deficiencies all of which deplete energy. PK diet and vitamin C to bowel tolerance to reduce the toxic load from the gut. Dr. Sarah Myhill, MD states, "Chronic fatigue syndrome is the symptom caused by mitochondrial failure." Mixing metaphors slightly, as is the tradition, it then only needs a final straw, a last demand or an unexpected infection, and suddenly your ship is in irons – sails flapping uselessly and the boat wallowing dangerously and with no steerageway. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Coenzyme Q10 is an energy molecule within our cells. This means oxygen levels in the blood coming from the left side of the heart drop and energy delivery is further impaired because of poor oxygen supply to the tissues. See. Co-Q10 should be taken with a fatty or oily meal. Remember, shortness of breath may also result from heart failure, respiratory distress and anaemia, and these symptoms need investigating as a separate issue. por elipoarch » 28 Jun 2011, 17:44, Mensaje There is the added bonus that dealing with them can convert them into virtuous circles. Coenzyme Q10 is a vital participant in the chain of metabolic chemical reactions that generat… See. It is also thought to be an important antioxidant. But nothing could be farther from the truth, except if you are an ill-treated type 1 diabetic person. Hyperventilation changes the acidity of the blood (it becomes more alkali) so that oxygen sticks more avidly to haemoglobin so worsening oxygen delivery. Ketones – contrary to popular belief and myth – are a much needed and essential healing energy source in our cells that come from the normal metabolism of fat. At rest the liver uses up 27 per cent of all the energy available to the body, compared with the brain at 19-20 per cent and the heart at 7 per cent. That enzyme, you don’t have to remember that, but that enzyme produces two products, 1) cholesterol, and 2) coenzyme Q10. ), Archimedes, Greek Mathematician, c 287 – 212 BC. My doctor thinks I have CFS. Coenzyme Q10 as ubiquinol – 100 milligrams daily; Vitamin B12 is an excellent antioxidant - 1 milligram (1000 micrograms) by daily injection. Coenzyme Q 10 is found naturally in our diets from foods, including fish, liver, kidney and the germs of whole grain. This is because 40 per cent of resting energy simply powers the ion pumps for sodium/potassium (Na/K) and calcium/magnesium (Ca/Mg) across cell membranes (an essential ongoing process for life). SíNDROME DE FATIGA CRÓNICA, FIBROMIALGIA, SQM Y OTROS, Sarah Myhill: Coenzima Q10 en Síndrome Fatiga Crónica, http://www.ijcem.com/files/IJCEM812001.pdf, http://www.prohealth.com/library/showar ... ibid=15057, https://helpify.es/comunidades/todo-por ... a-cronica/, Re: Sarah Myhill: Coenzima Q10 en Síndrome Fatiga Crónica. If you’re going to try a supplement ubiquinol is the most absorbable form of coenzyme Q10, and because it’s a fat soluble molecule it’s best taken in an oil filled capsule. One to one menopause help. Si no entiendo mal, la Acetil L-Carnitina es la L-Carnitina medio procesada. He (and normally it is a he too!) por cacoya » 28 Jun 2011, 17:57, Mensaje The business of dealing with toxins requires energy – and a lot of it. Magnesium deficiency is common in CFS/ME sufferers and may result from hyperventilation – so we may have a vicious circle within a vicious circle! Remember that. Reduce demands – pace as well as possible. J Am Coll Cardiol 2007;49:2231-7. Tyrosine is also a building block of thyroid hormones. There is an obvious financial/social/biologically plausible circle here which is as follows: The longer one is ill --> the less money one has (loss of job, or cutting down hours) and the more chance there is of more biological systems becoming dysfunctional --> one has less money to deal with potentially more problems --> one becomes more ill as issues are not addressed --> potentially the less money one has (loss of job, or cutting down hours) and the more chance there is of more biological systems becoming dysfunctional --> …. However, the absorption of both of these common toxic metals, for example, is greatly enhanced by the fermenting gut. Dr. Klimas warns against using it before going to bed. Por favor me gustaría saber si hay forma de poder traducir esta informacion. Poor energy delivery as a result of poor mitochondrial function --> insufficient energy to drive the ion pumps for sodium/ potassium (Na/K) and calcium/magnesium (Ca/Mg) across cell membranes --> magnesium cannot be drawn into cells for oxidative phosphorylation to work --> energy delivery further impaired because the release of energy from ATP is magnesium dependent, as is the synthesis of ATP from ADP --> …. The richest natural sources of dietary coenzyme Q10 are meat, poultry and fish, but vegetarian options, such as beans, nuts, some vegetables, eggs and dairy products, are also helpful for increasing your intake. Some of these toxins are external to the body, whereas others are caused by the fermenting gut, itself a result of an incorrect diet (high carbs and sugar, etc). You must pace better! There it plays a central role in the electron transport chain (ETC), a process which is how animal and plant cells produce the bulk of their energy.The highest concentrations of CoQ10 are found in our vital orga… Caso G, Kelly P, McNurlan MA, et al. You have to get it all right to restore normal sailing. First, we are exposed to them – the two commonest examples are mercury from dental amalgam and lead from drinking water. Myhill asserts that Co-Q10 works best when used with magnesium, D-Ribose, acetyl L … If you overspend you have to temporarily borrow from the lactic acid loan shark - otherwise known as Anaerobic metabolism! Dr. Sarah Myhill is a UK-based physician with a special interest in fatigue and nutrition. Menopause Help Available. Coenzyme Q10 supplements can boost fertility in both men and women. But, according to Valerius Maximus (Facta et dicta memorabilia, Book VIII.7), Archimedes just answered "Noli, obsecro, istum disturbare" ("Do not, I entreat you, disturb that (sand)"), because he was so engrossed in the circles drawn on the sand in front of him. The sufferer protects him/herself from the pain by moving slowly. As Dr. Greger says, the best way to maintain your level of CoQ10 may be to eat more plant-based, chlorophyll-rich diets. One of the products of a fermenting gut is hydrogen sulphide and this sulphide converts poorly absorbed inorganic metals into well-absorbed organic metals with the potential to bio-accumulate. This bio-accumulation is worse when the body is deficient in friendly trace elements – if it cannot, for example, access zinc for enzyme systems then the body will grab something which ‘looks’ similar, such as arsenic or nickel. por JW juan » 19 Mar 2018, 15:18, Volver a “SUPLEMENTOS / COMPLEMENTOS ALIMENTICIOS”, Desarrollado por phpBB® Forum Software © phpBB Limited, [t]Dr. Sarah Myhill on Coenzyme Q10 in Chronic Fatigue Syndrome (ME/CFS)[/t]. When the Romans conquered the city of Syracuse after the siege of 214–212 BC, the Roman general Marcus Claudius Marcellus ordered the soldiers to retrieve Archimedes. Sarah Myhill on Coenzyme Q10 in Chronic Fatigue Syndrome (ME/CFS)” tojomo says: September 19, 2011 at 10:50 am. Every cell in your body has a power plant. See, Improve mitochondrial function as above - mitochondrial bolt on package. Much of this energy is for detoxification. The diagnosis is made more difficult because there are often delayed reactions, which start 24 or 48 hours after allergen exposure and last for several days. If you have never tried d-ribose yet, it is well worth a try. Loss of self-esteem and self-worth, accompanied by feelings of inadequacy --> Further inability to cope with situations because of reduced 'emotional resilience' as a consequence of reduced self-esteem and self-worth --> Further loss of self-esteem and self-worth, accompanied by feelings of inadequacy --> …. Learn to identify them and use this knowledge to make you even more determined. Alongside rest, and drinking "plenty of fluids", Dr Chris recommends two supplements. Coenzyme Q10 (CoQ10) is an antioxidant that your body produces naturally. Additional micronutrients to improve antioxidant status, viz: Superoxide dismutase – copper 1 milligram, manganese 3 milligrams and zinc 30 milligrams for 4 months to correct a deficiency. Over and above the basic package of supplements this would include glutathione 250mgs. This in turn means that the body will be able to call on fewer of these powerful antioxidants, thereby weakening its own detox systems. There is no official Daily Value recommendation, but Dr. Weil suggests at least 90 to 120 mg of supplemental CoQ10 for any adult taking statin medications and for those with a family history of heart problems, or who is at increased risk for cardiovascular disease. Ketosis is an often misunderstood subject. If injections are not possible, then transdermal B12 spray - see Sales at Dr Myhill Transdermal B12 spray According to Dr Sarah Myhill (11) the synthesis of this molecule can be inhibited by chronic illness and toxins. See, Taking the basic package of supplements: multivitamins, multiminerals and essential fatty acids – many are used in the liver for detoxing and to improve antioxidant status. This may result in hyperventilation, which actually makes the situation worse. Try to do what you can and pick the easy and cheap (er) things first. It’s rare to have side effects because it’s a natural substance. If you want, you can watch the video from Dr. Greger for a full explanation of this fascinating finding. At that poin, a lower does can be used. Sales at Dr Myhill stocks all the above nutritional supplements, Co Q-10, Mineral Mix,.D-ribose, acetyl L-carnitine and NAD, as well as many other products. There is a general belief that a high fat diet results in high cholesterol, which results in arterial and heart disease. Strictly speaking it is not a hole but a valve which should snap shut and stick shut at the moment of birth. This is a hole in the heart between the left and right atria (which normally closes as a flap at birth); this means that blood bypasses the lungs and does not pick up oxygen as it should. So it is with recovering from CFS/ME and this is illustrated by modelling the situation with catastrophe theory – see Catastrophe theory: why we get into and how we get out of CFS. [See Quote below]. The same enzyme in the liver which is called HMG coenzyme A reductase enzyme. Other muscles in the vicinity of the allergic muscles may also go into spasm to protect against sudden inadvertent stretching and this causes a more generalised muscle spasm and stiffness. Initially any stretch will cause it; then, as things settle down, only a sudden stretch will do that. For some people, the valve does not stick – it remains as a flap. See Diet, Detox and Die-off Reactions - expect to get worse. Gracias. CFS - The Central Cause: Mitochondrial Failure ... coenzyme Q10 and lipids designed to help regenerate the mitochondrial inner membrane are all helpful in the treatment of CFS/ME. Dr.Max Coenzyme Q10 60 mg 60 kapslí Doplněk stravy Kapsle s obsahem koenzymu Q10 a vitaminu B1 (thiaminu). 249 Kč . This means that the synthesis of super-oxide dismutase, dependent on zinc, or glutathione peroxidase, dependent on selenium, will both be less efficient. After reading about statins and coenzyme Q10, a reader commented that she knew of at least sixteen women in their 40s who successfully became pregnant while taking coenzyme Q10 supplements. Poor mitochondrial function --> heart is weak (the heart is a muscle packed full of mitochondria to ensure good function) --> pressure difference between left and right artria is lost --> valve may blow open --> blood does not circulate round the lungs but short cuts back to the left side of the heart --> oxygen levels drop --> energy delivery is impaired --> poor mitochondrial function -->….. So, a torn muscle in the back from, say, lifting a heavy load, could sensitise to, say, dairy products, and it is the consumption of dairy subsequently which keeps the problem on the boil. See this checklist and be as rigorous as you can on Stage 2 -, Essentially this means doing as much of Groundhog BASIC as possible – see, Then as you feel better you can gradually add in new interventions, BUT the best way – easier said than done – is to never get into this situation in the first place. Muscles can only react in one way, which is with contraction, and this can vary from low grade cramp and muscle tics or jumping, to acute lancinating pain. This goes unrecognised by cardiologists who call it “atypical cardiac pain”. CoQ10 may potentially boost heart health in multiple ways, from decreasing high blood pressure to slowing the progression of … Poor energy delivery due to poor mitochondrial function --> poor detoxification --> more toxins remain present in the body’s systems --> worsening energy delivery mechanisms --> …. The commonest cause of this is the adrenalin of falling blood sugar in those running their bodies on carbohydrates. por elipoarch » 28 Jun 2011, 19:24, Mensaje Then we absorb them. Coenzyme Q10 is a compound that helps your cells make energy. It was also be… So what are those common vicious cycles? CFS/ME – Vicious circles and multitasking, Sarah’s book ‘Diagnosis and Treatment of CFS and ME – it’s mitochondria not hypochondria!’, The Paleo Ketogenic Diet - this is a diet which we all should follow, Our book 'The PK Cookbook - Go Paleo-ketogenic and get the best of both worlds', Healing the Emotional Hole in the Energy Bucket, Vitamin C - learn to use this vital tool well – the key is getting the dose right, Nutritional Supplements - what everybody should be taking all the time even if nothing is wrong, Sales at Dr Myhill Transdermal Magnesium Spray, http://drmyhill.co.uk/drmyhill/index.php?title=Vicious_circles_in_CFS/ME&oldid=19967, Women's health, fertility and healthy babies, Feed mitochondria their preferred fuel which are ketones ie the PK diet - see, Give mitochondria the raw materials to function with the mitochondrial bolt on package, Coenzyme Q10 as ubiquinol – 200 milligrams, Vitamin B3 as niacinamide – 500-1500 milligrams – slow release, D-ribose – up to 15 grams (but this must be part of the carb count of the PK diet), Vitamin B12 – 5 milligrams sublingually or ideally B12 by injection, Magnesium – ½ ml 50% magnesium sulphate by injection, ideally, together with 300mg orally and vitamin D 10,000iu daily to enhance absoprtion, Identify blockages – the common ones are products of the fermenting gut, pesticides and VOCs (can be got rid of with heating regimes - see, Look at the control mechanisms – thyroid accelerator pedal and the adrenal gearbox see, Improve the mitochondria as above - mitochondrial bolt on package, Hyperventilation is adrenalin driven. no me lo puedo creer.. llevo muchos años con dolor de piernas y después de dos- tres semanas tomando Q10 se me ha ido un 80% de dolor.. años tomando medicamentos para la circulación, ibuprofenos para poder dormir unas horas, duchas frías, etc, Estoy emocionada con este hallazgo. Much of the text, and all the thinking, is taken from Sarah’s book ‘Diagnosis and Treatment of CFS and ME – it’s mitochondria not hypochondria!’. Possibly, for example, polymyalgia rheumatica is muscles becoming allergic to gut microbes. Once again, please accept my deepest apologies if I have seemed to trivialise what can be a truly awful situation. Taking Vitamin C - increases excretion of toxic metals in urine. It will take about 4 weeks for levels to plateau. Consider psychological interventions (counselling etc) but choose your counsellor well and make sure that they understand that CFS/ME is a physical illness and that psychological interventions do not cure CFS/ME but rather may help with dealing with the awful consequences. There is also a new form of CoQ10 that is referred to as Pyrroloquinoline quinone (PQQ) that some claim to be more effective. CoQ10 levels have also been found to be lower in people with certain conditions, such as heart disease.CoQ10 is found in meat, fish and whole grains. Typically, this just lasts a few seconds. Historical Note - According to Valerius Maximus, the phrase was uttered by Archimedes. Have great week. This is an interesting article by Dr. Myhill. The following Chronic Fatigue Syndrome specialists recommend taking Coenzyme Q10 dietary supplements for CFS: Dr Cheney, Dr Teitelbaum, Dr Pall, Dr Downing-Orr and Dr Myhill. Our bodies make CoQ10, though less as we age, and store it in our mitochondria. Lot of it try to do what you can watch the video from Dr. Greger says, best... Studies have shown that CoQ10 may be to eat more plant-based, chlorophyll-rich diets body has power... Produces naturally things at the moment of birth it before going to bed may expect detoxification to... 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